Michael Brennan, DDS, MHS

The objective of this study is to determine if an Intensive Preventive Dental Program (IPDP) administered in an oncology practice can reduce dental disease in patients with head and neck cancer post-radiation therapy compared to current oncology care practice that occurs post radiation therapy. I am currently the co-PI of Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (ORARAD- U01DE022939) and of a prospective multicenter study- Oral Complications in Stem Cell Transplant Patients: ORASTEM, which has funding from the Swedish Government: Western Region of Public Dental.  I am also the lead investigator for a recent Phase I and a current Phase II study to determine the efficacy of gene therapy treatment in subjects with radiation-induced parotid gland hypofunction and xerostomia.  I have also successfully completed the pilot interventional study to assess IPDP in an oncology practice.   My current and previous roles as co-PI and PI for observational studies and clinical trials in head and neck cancer patients has provided me the experience and expertise needed to lead the development and successful enrollment and completion of the current proposed interventional study. My experience and expertise in oral oncology will allow for the successful dissemination of findings through manuscripts/presentations.